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17 February 2012

Further information


The NC3Rs leads the discovery, development and promotion of new ways to replace, reduce and refine the use of animals in research and testing (the 3Rs) – supporting science and innovation in the bioscience sector. We are an independent organisation sponsored by Government and the UK’s major funder of 3Rs research.

This year the Centre is funding 15 PhD studentships. The successful research groups are now looking to recruit highly motivated candidates. Applicants should hold, or realistically expect to obtain, at least an Upper Second Class Honours degree in the biological sciences. They should also have a desire to pursue research in line with that of the research groups.

Funding will provide full support for tuition fees, associated project costs, and an annual tax-free stipend.

University of Glasgow:
The development of an in vitro model of spinal cord injury to study aligned neurite outgrowth using induced pluripotent stem cells (iPSC) as a replacement for in vivo models to screen novel therapies which target self-renewal pathways in chronic myeloid leukaemia.

Imperial College London:
Developing a novel model to assess the specificity of appetite-reducing agents in vitro and in silico models of gut bacterial diversity and its impacts on human health
Improving the principles of the 3Rs through new integrative metabolomic and gene
expression resources for signalling studies in burn injuries.

King’s College London:
Characterisation and validation of an organotypic slice culture model of Alzheimer’s disease.

Liverpool School of Tropical Medicine:
Refining, reducing and replacing in vivo WHO-standard preclinical assays of snake
venom pathology and antivenom efficacy.

Loughborough University:
Combinatorial mathematical modelling and novel toxicological profiling of drug-induced hepatotoxicity.

University of Manchester:
Reducing animal dependency in diabetes research through pancreatic stem cells.

Newcastle University:
Refinement of the use of fluid control as a motivational tool for non-human primates in neuroscience research.

University of Nottingham:
Construction of a miniaturized human lymph node model as an alternative to the local lymph node assay.

University of Oxford:
A Drosophila model of Candida albicans gastrointestinal infection development of a non-animal model for characterizing drug-resistant tumours.

Queen's University Belfast:
Development of non-radioactive labels for a receptor binding assay for paralytic shellfish poisoning (PSP) toxin testing.

University of Southampton:
Bone healing and regeneration in an ex vivo bioreactor - evaluation of angiogenesis and reparation for clinical application.

For further information, including details of project supervisors, please click 'Find out more’.


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