MRC MRes/PhD Studentship: Derivation of Human Hepatocytes from Pancreatic Progenitor Cells and their use in a Novel Antioxidant Screening Platform.
- Newcastle Biomedicine
- Reference Code: CL050
Name of the supervisor(s)
Dr P Manning, ICM ,
Professor M Wright, ICM
Professor C McNeil, ICM
Duration of the award
4 years (MRes Medical and Molecular Biosciences followed by a three-year PhD)
This integrated MRes/PhD studentship has two central aims: a) to derive fully characterised human hepatocytes form pancreatic progenitor cells and b) to use these human hepatocytes as part of a novel analytical platform that will assess the potential link between hepatocyte production of reactive oxygen species (ROS) and inflammatory liver disease.
The ability to chemically convert pancreatic cells into hepatocytes has already been proven in animal models at Newcastle University. This studentship will primarily aim to reproduce these findings using cells derived solely from human tissue.
Hepatocellular production of ROS will subsequently be measured using two innovative sensing technologies. Intracellular detection will be based on fluorescent nanosensors that respond selectively to the ROS superoxide (O2??) and nitric oxide (NO). Extracellular detection will be achieved by using ROS specific electrodes. Combining these technologies will provide real-time data that could result in a greater understanding of the connection between ROS production and liver pathology.
The supervisory team for this MRes/PhD has recently secured ?10.9M of funding to co-ordinator an EU FP7 project entitled: 'Information and Communication Technology (ICT)-enabled, cellular artificial liver system incorporating personalised patient management and support (D-LIVER)'. The successful candidate will work closely with the D-LIVER project team. This will offer an excellent opportunity to work with internationally renowned specialists in medicine, engineering and other disciplines related to translational research.
Value of the Award and Eligibility
Depending on how you meet the MRC's eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,590 (2011/2012). A partial award covers fees at the UK/EU rate only.
You should have, or expect to achieve, a first-class, or upper-second-class, Honours degree in a relevant discipline relating to biomedical sciences.
How to Apply
You must complete the University's postgraduate application form . Select "Master of Research/Doctor of Philosophy (Medical Sciences) - Cellular Medicine" as the programme of study. Only mandatory fields need to be completed (no personal statement required) but you must attach a copy of your CV and a covering letter, quoting the title of the studentship and reference number CL050.
Closing date for applications
Prompt application is advised as this post is only available until a suitable candidate is appointed.
For further details, please contact Dr P Manning, firstname.lastname@example.org , +44 (0) 191 222 8520