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BBSRC MRes/PhD Studentship - Simplified in-process detection of protein higher order structure and aggregation

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Newcastle University
28 June 2012
. .
Newcastle Upon Tyne, Tyne and Wear
Earth, Environment & Energy

Further information

BBSRC MRes/PhD Studentship - Simplified in-process detection of protein higher order structure and aggregation
Reference Code:


Name of the supervisor(s)
Professor J Lakey, Institute for Cell and Molecular Biosciences
Dr P Levison, Pall Life Sciences


Duration of the award
Funding expected for a 4 year (MRes Medical and Molecular Biosciences followed by 3 year PhD). If the candidate already has a suitable masters qualification then 4 year PhD).

Project description
The bioprocessing industry supplies therapeutic proteins and cell lines to the healthcare sector. They are at the forefront of the move from small molecule drugs to biopharmaceuticals exemplified by therapeutic antibodies such as Herceptin, hormones such as insulin and novel vaccines. The BRIC Doctoral Training Programme aims to improve the supply of skills to industry and academia in the bioprocessing sector, by providing a PhD programme that includes structured training that exposes students to industrial practices and needs.

This studentship will be based in the Institute for Cell and Molecular Biosciences and combine a full PhD training with extended work placements in Pall Life Sciences in the UK and abroad. The student will also attend the BRIC doctoral training school which is an intensive week-long course providing industrially relevant transferable skills.

The research project aims to develop methods that rapidly and easily detect changes in protein structure including aggregation. These are currently measured using expensive methods unsuitable for use on the production line. Instead the project will build upon preliminary work which showed that bench top methods could detect these changes simply and inexpensively. To do this work the student will be trained in a range of methods spanning molecular biology, protein purification, structural analysis and industrial processes.

Students with a qualification in biochemistry, other molecular biosciences or chemistry, and who are interested in joining an expanding industrial sector, are encouraged to apply.

Value of the Award and Eligibility
Depending on how you meet the BBSRC’s eligibility criteria, you may be entitled to a full or a partial award. A full award covers tuition fees at the UK/EU rate and an annual stipend of £13,590 (2012/13). A partial award covers fees at the UK/EU rate only.

Person Specification
Candidates should have or expect to achieve a First class or 2:1 honours degree preferably in biochemistry but applicants with degrees in molecular biosciences or chemistry are also encouraged to apply.

How to Apply
You must complete the University's postgraduate application form. Select "Master of Research/Doctor of Philosophy (Medical Sciences) – Cell and Molecular Biosciences” as the programme of study. Only mandatory fields need to be completed (no personal statement required) but you must attach a copy of your CV and a covering letter, quoting the title of the studentship and reference number CB081.

Closing date for applications
Prompt application is advised as this post is only available until a suitable candidate is appointed.

Further Information
For further details, please contact:
Professor J Lakey,, +44 (0) 191 222 8865

Newcastle University

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